研究成果バックナンバー
2016年/2015年/2014年/2012年/2011年/2010年/2009年/2008年/2007年/2006年/2005年/2004年以前

2016年

*施設教員の共同研究の論文が受理されました*
(2016.1.22)
Okamoto, M. and Mizukami, Y., GPER negatively regulates TNFα-induced IL-6 production in human breast cancer cells via NF-κB pathway, Endocrine J., 63(5), 485-93 (2016) (IF=1.997)

2015年

*施設教員の共同研究の論文が受理されました*
(2015.11.26)
Mimura, et al, Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines, J. Immunol Methods, Nov.26 in press (IF=1.820)

*施設教員の共同研究の論文が掲載されました* (2015.5.24)
Utada, K., et al, The combination of insulin-like growth factor 1and erythropoietin protects against ischemic spinal cord injury in rabbits, J. Anesthesia, 29, 741-748 (2015). Epub 2015 May 24(IF=1.176)

2014年

*施設教員の共同研究の論文が掲載されました*
(2014.8.18)
Akiyoshi Y., Izumi T., Oda Y., Mizukami Y., Tsuruta R., Maekawa T., Analysis of cerebrospinal fluid proteins reveals association of calbindin 1 concentrations with neurological outcome in patients resuscitated from cardiopulmonary arrest: A proteomics based pilot study
Yamaguchi Med. J. Bulletin. in press (2014)

*施設教員の総説が受理されました*
(2014.7.31)
狩生徹,井上雄太郎,水上洋一, 半導体マイクロチップ対応次世代シーケンサーを用いたがん関連遺伝子の解析
山口医学. 63 (4),253-256,(2014)

*施設教員の著書が掲載されました*
(2014.5.30)
水上洋一, 渡邉健司, 坂口修一, ―次世代シーケンサーの現状と問題点について-
遺伝子・DNA利用も製品開発におけるガイドラインでは分からない規制・倫理対応と解析、操作技術のトラブル対策(株)技術情報協会 編. 第5章10節,(2014)

*施設教員の共同研究の論文が掲載されました*
(2014.3.7)
Nakashima, T., Ohkusa T., Yoshida M., Lee J.-K., Mizukami Y., Yano M., Alterations in cardiac β-catenin precede connexin gap junction remodeling in cardiomyocytes exposed to rapid electrical stimulation
Am. J. Physiol. (Heart and Circulatory Physiology). 306 (9),H1324-33,(2014)[Epub ahead of print] (IF=4.012)

2012年

*施設教員の共同研究の論文が掲載されました*
(2012.4.16)
Aihara M, et al, Optimizing high-resolution melting analysis for the detection of mutations of GPR30/GPER-1 in breast cancer
Gene. 501(2),118-126,(2012)[Epub ahead of print] (IF=2.341) <http://www.ncbi.nlm.nih.gov/pubmed/22525040>

2011年

 

*施設教員の共同研究の論文が掲載されました*
(2011.7.27)
Yoshida M, et al, Alterations in adhesion junction precede gap junction remodelling during the development of heart failure in cardiomyopathic hamsters.
Cardiovasc Res. 2011 Jul 27.[Epub ahead of print] (IF=6.051) <http://www.ncbi.nlm.nih.gov/pubmed/21693625>


*施設教員の共同研究の論文が掲載されました*
(2011.4.20)
Takemoto Y,et al., Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells.
Surgery. 2011 Jun;149(6):792-800. 2011 Apr 20.(IF=3.406) <http://www.ncbi.nlm.nih.gov/pubmed/21507448>


*施設教員の依頼原稿が掲載されました*
(2011.9.1)
水上洋一、細胞膜エストロゲン受容体GPER/GPR30はなぜ小胞体で見つかったのか!
日本薬理学会誌, 138(3), 130 (2011)


2010年

*施設教員の論文が掲載されました*
(2010.8.5)

Katagiri, T., et al, Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry.
Proteome Sci., Jul 27; 8:41, 2010 (IF=2.56) <http://www.ncbi.nlm.nih.gov/pubmed/20659346>

*施設教員の総説が掲載されました*
(2010.4.5)

岡本まり子, IL-4産生素因と遺伝子レプレッサーmina
臨床免疫・アレルギー科, 53, 205-213, 2010

2009年

*施設教員の総説が掲載されました*
(2009.12.26)

Mizukami, Y., In Vivo Functions of GPR30/GPER-1, a Membrane Receptor for Estrogen: From Discovery to Functions In Vivo,
Endocr J.,57, 101-107, 2009

*施設教員との共同研究の論文が掲載されました*
(2009.9.27)

Yamashita, S., et al, Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase,
Brain Res.,1301, 171-179, 2009

*施設教員の総説が掲載されました*
(2009.8.27)

水上洋一, 性ステロイドホルモンとGPCR―エストロゲン新規受容体GPR30に関する最近の知見―
実験医学 8月号 (2009)

*施設教員の論文が掲載されました*
(2009.8.13)

Okamoto, M., et al, Mina, an Il4 repressor, controls T helper type 2 bias
Nature Immunology, 10, 872-879, 2009 (IF=25.113)

*施設教員の論文が掲載されました*
(2009.7.13)

Okamoto, N., Okamoto, M., et al, Possible contribution of DNase gamma to immunoglobulin V gene diversification
Immunology Letters, Jun. 30, 2009 (IF=2.858)

*施設教員との共同研究の論文が受理されました*
(2009.2.24)

Matayoshi, H.,et al., Neurtrophil elastase inhibitor, ONO-5046, attenuates hippocampal neuronal damage after transient forebrain ischemia in rats
Brain Res. 1259, 98-106 (2009)(IF=2.218)
>>PDFファイル

*施設教員との共同研究の論文が受理されました*
Yamashita, S., Hirata, T., Mizukami, Y. Cui, Y.J., Fukuda, S., Ishida, K., Matsumoto, M., Sakabe, T., Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase
Brain Res., 1301, 171-179 (2009)


2008年

*遺伝子実験施設教員の論文が受理されました*
(2008.6.11)
心臓の虚血時に放出される不整脈抑制(生存)因子を同定
Mizukami, Y., et al, Identification and physiological activity of survival factor released during ischemia and reperfusion
Cardiovasc, Res., 79(4):589-599 (2008) (IF=5.826)
>>PDFファイル

*遺伝子実験施設教員の論文が受理されました*
(2008.6.5)

オーファン受容体TPRA40/GPR175の細胞膜移行の制御因子を同定
Aki, T., et al  TPRA40/GPR175 regulates mouse early embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14,
J. Cell Physiol., 217, 194-206 (2008) (IF=3.64)
>>PDFファイル

*施設教員が研究費の助成を受けました*
(2008.3.31)
遺伝子実験施設職員が研究費の助成を受けました。
ノバルティス科学振興財団・研究奨励金入選
新規細胞膜女性ホルモン受容体欠損マウスにおける心血管障害
代表 水上洋一

*共同研究の論文が掲載されました*
(2008.2)
Tonooka, Y. et al., , One-base excess adaptor ligation method for walking uncloned genomic DNA
Appl. Microbio. Biotechnol, 78(1):173-180 (2008)(IF=2.441)

*共同研究の論文が掲載されました*
(2008.1)
Nishina, S et al., Hepatitis C virus-induced reactive oxygen species causes hepatic iron accumulation by reducing hepcidin transcription
Gastroenterology, 134(1), 226-238 (2008)(IF=12.457)



2007年

・Hirata,T., Cui, J. Y., Funakoshi, T., Mizukami, Y., Ishikawa, Y., Shibasaki, F., Matsumoto, M., Sakabe, T., Temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen
Brain Res., 1130 (1) 214-222 (2007)


2006年

・Funakoshi, T., Yanai, A., Shinoda, K., Kawano, M.M., Mizukami, Y.,
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane
Biochem. Biophys. Res. Communi. 346, 904-910 (2006) (corresponding author)


2005年

・Hara, K., Okamoto, M., Aki, T., Yagita, H., Tanaka, H., Mizukami, Y., Nakamura, H., Tomoda, A., Hamasaki, N., Kang, D., Synergistic enhancement of TRIL- and tumor necrosis factor a-induced cell death by a phenoxazine derivative
Mol. Cancer Ther. 4 (7), 1121-1127 (2005)


2004年以前

Mizukami, Y., Sumimoto, H., and Takeshige, K., Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells
Biochem. Biophys. Res. Commun.
314, 104-109 (2004) (corresponding author)

・Yoneda, K., Iwamura, R., Kishi, H., Mizukami, Y., Mogami, K., Kobayashi, S., Identification of active metabolite of ticlopidine from rat in vitro metabolites
Brit. J. Pharmacol., 142(3):551-557 (2004)

Mizukami, Y., Iwamatsu, A., Aki, T., Kimura, M, Nakamura, K., Nao, T., Ohkusa, T., Matsuzaki, T., Yoshida, K., Kobayashi, S., ERK1/2 regulates intracellular ATP levels through a-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation
J. Biol. Chem.
, 279
, 50120-50131 (2004) (corresponding author)

・Eguchi, M., Fujiwara, M., Mizukami, Y., and Miwa, N., Cytoprotection by pro-vitamin C against ischemic injuries in perfused rat heart together with differential activation of MAP kinase family
J. Cell. Biochem
., 89, 863-867 (2003)

・Aki, T., Yamaguchi K., Yoshida, K., Fujimiya, M., Mizukami Y., Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2
Oncogene
, 22, 8529-8535 (2003)

・Aki, T., Yoshida, K., and Mizukami, Y., The mechanism of aB-Crystallin gene expression by proteasome inhibition
Biochem. Biophys. Res. Commun
. 311, 162-167 (2003)

・Shirao, S., Kashiwagi, S., Sato, S., Miwa, S., Nakao, F., Kurokawa, T., Todoroki-Ikeda, N., Mogami, K., Mizukami, Y., Kuriyama, S., Haze, K., Suzuki, M., Kobayashi, S., Sphingophosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+-sensitization in the bovine cerebral artery: unimportant role for protein kinase C
Circ. Res.,91(2):112-119 (2002)

・Nakao,F., Kobayashi, S., Mogami, K., Mizukami, Y., Shirao, S., Miwa, S., Todoroki-Ikeda, N., Ito, M., Matsuzaki, M., Involvement of Src Family Protein Tyrosine Kinases in Ca2+-Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway
Circ. Res.,
91, 953-60 (2002)

Mizukami, Y., Yamada, S., Takashima, M., Kokudo, N., Yokoyama, T., Dietry iron reduces anti-convulsion activity of phenytoin in electrconvulsion via inhibition of brain penetration
Brain Res., 915, 112-117 (2001) (corresponding author)

・Fujimoto, K., Mizukami, Y., Kimura, M., Todoroki-Ikeda, N., Mogami, K., Kobayashi, S., and Matsuzaki, M., Molecular cloning of rat transmembrane domain 40-kDa regulated in adipocytes and its expression in H9c2 cells exposed to ischemic hypoxia and reoxygenation
Biochim. Biophys. Acta.(Gene Structure & Expression), 1518, 173-177. (2001) (corresponding author)

・Omura, M., Kobayashi, S., Mizukami, Y., Mogami, K., Todoroki-Ikeda, N., Miyake, T., and Matsuzaki, M., Eicosapentaenoic acid (EPA) induces Ca2+-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent relaxation
FEBS Lett., 487, 361-366 (2001)

・Kimura, M., Mizukami, Y., Miura, T., Fujimoto, K., Kobayashi, S., and Matsuzaki, M., G-protein-coupled receptor, GPR41, induces apoptosis via a p53/Bax pathway during ischemic hypoxia and reoxygenation
J. Biol. Chem., 276, 26453-26460 (2001) (corresponding author)

Mizukami, Y., Okamura, Y., Miura, T., Kimura, M., Mogami, K., Todoroki-Ikeda, N., Kobayashi, S, and Matsuzaki, M., Phosphorylation of proteins and apoptosis induced by c-Jun N-terminal kinase activation in H2O2 stimulation
Biochim. Biophys. Acta. (Molecular Cell Research), 1540, 213-220. (2001) (corresponding author)

・Aki, T., Mizukami, Y., Oka, Y., Yamaguchi, K., Uemura, K., Fujimiya, T., and Yoshida, K., Phosphatidylinositol 3-kinase accelerates necrotic cell death during hypoxia
Biochem. J., 358, 481-487(2001)

Mizukami, Y., Kobayashi, S., berall, F., Karina, H., Kobayashi, N., and Yoshida, K., Nuclear mitogen-activated protein kinase activation by protein kinase C z during reoxygenation after ischemic hypoxia and reoxygenation
J. Biol. Chem., 275, 19921-19927 (2000) (corresponding author)

・Todoroki-Ikeda, N., Mizukami, Y., Mogami, K., Kusuda, T., Yamamoto, K., Miyake, T., Sato, M., Suzuki, S., Yamagata, H., Hokazono, Y., Kobayashi, S., Sphingosylphosphorylcholine induces  Ca2+-sensitization of vascular smooth mucle contraction: Possible involvement of Rho-kinase
FEBS Lett., 482, 85-90  (2000)

・Yoshida, K., Mizukami, Y., and Kitakaze, H., Nitric oxide activates protein kinase C isoforms in ischemic heart
Biochim. Biophys. Acta. 1453, 230-238 (1999)

・Mogami, K., Mizukami, Y., Todoroki-Ikeda, N., Ohmura, M., Yoshida, K., Miwa, S., Matsuzaki, M., Matsuda, M., and Kobayashi, S., Sphigosylphosphorylcholine induces cytosolic Ca2+ elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery
FEBS Lett
., 457, 375-380 (1999)

・Kawamura, S., Yoshida, K., Miura, T., Mizukami, Y., and Matsuzaki, M., Ischemic preconditioning translocates PKC-d and e that mediates functional protection in isolated rat heart
Am. J. Physiol. (Heart and Circulatory Physiology), 275, H2266-H2271 (1998)

・Kikuta, Y., Kusunose, E., Sumimoto, H., Mizukami, Y., Takeshige, K., Sakaki, T., Yabusaki, Y., Kusunose, M., Purification and characterization of recombinant human neutrophil leukotriene B4 w-hydroxylase
Arch. Biochem. Biophys., 355, 201-205 (1998)

・Kawata, Y., Mizukami, Y., Fujii, Z., Sakumura, H.,Yoshida, K., and Matsuzaki, M., Applied pressure induces cell proliferation through mitogen-activated protein kinase activation in rat mesangial cell
J. Biol. Chem., 273, 16905-16912 (1998) (corresponding author)

Mizukami, Y., Yoshioka, K., Morimoto, S., and Yoshida, K., A novel mechanism of JNK1 activation: Nucler translocation and activation of JNK1 during reperfusion
J. Biol. Chem., 272, 16652-16662 (1997) (corresponding author)

・Yoshida, K., Kawamura, S., Mizukami, Y., and Kitakaze, M., Implication of PKC isoforms in ischemic precondioning
J. Biochem.(Tokyo), 122, 506-511 (1997)

Mizukami, Y. and Yoshida, K., Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion
Biochem. J., 323, 785-790 (1997) (corresponding author)

Mizukami, Y., Hirata, T., and Yoshida, K., Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase
FEBS Lett., 401, 247-251 (1997) (corresponding author)

・Yoshida, K., Hirata, T., Akita, Y., Mizukami, Y., Yamaguchi, K., Sorimachi, Y., Ishihara, T., and Kawashima, S., Translocation of protein kinase C-α, δ, and ε isoforms in ischemic rat heart
Biochim. Biophys. Acta, 1317, 36-44 (1996)

Mizukami, Y., Sumimoto, H., Isobe, R., Minakami, S. and Takeshige, K., ω-Oxidation of lipoxin B4 by rat liver: Identification of ω-carboxy metabolite of lipoxin B4
Eur. J. Biochem. 224, 959-965 (1994)

Mizukami, Y. and Yokoyama, T., A study on the bactericidal activity of povodone-iodine : Morphological changes in Escheritia coli caused by povidone-iodine
Med. Electron Microsc., 26, 111-115 (1993) (corresponding author)

水上洋一、横山照由、合成培地によるポビドンヨードの抗菌力に関する研究
感染症学雑誌、 67, 1052-1056 (1993) (corresponding author)

・Sumimoto, H., Isobe, R., Mizukami, Y. and Minakami, S., Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes
FEBS Lett., 315, 205-210 (1993)

Mizukami, Y., Sumimoto, H., Isobe, R. and Minakami, S., ω-Hydroxylation of lipoxin B4 by human neutrophil microsomes : Identification of ω-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 ω-hydroxylase (cytocrome P-450LTBω)
Biochim. Biophys. Acta (Molecular & Cell Biology of Lipids), 1168, 87-93 (1993)

・Etoh, S., Noda, H., Minemoto, M., Noda, A. and Mizukami, Y., Optical separation of racemic 5-(hydroxy phenyl) phenylhydantoin by reversed phase high-performance liquid chromatography using eluents containing β-cyclodextrin
Chem. Pharm. Bull., 39, 2742-2744 (1991)

・Ishibashi, H., Takamuro, I., Mizukami, Y., Irie, M., and Ikeda, M. A convenient general access to α-sulfenylated acetophenones and alkanones
Synthetic Communications, 19, 443-452 (1989)