研究業績

論文

1. Ishibashi, H., Takamuro, I., Mizukami, Y., Irie, M., and Ikeda, M. A convenient general access to α-sulfenylated acetophenones and alkanones, Synthetic Communications, 19, 443-452 (1989)
2. Etoh, S., Noda, H., Minemoto, M., Noda, A. and Mizukami, Y., Optical separation of racemic 5-(hydroxy phenyl) phenylhydantoin by reversed phase high-performance liquid chromatography using eluents containing β-cyclodextrin, Chem. Pharm. Bull., 39, 2742-2744 (1991)
3. Mizukami, Y., Sumimoto, H., Isobe, R. and Minakami, S., ω-Hydroxylation of lipoxin B4 by human neutrophil microsomes : Identification of ω-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 ω-hydroxylase (cytocrome P-450LTBω), Biochim. Biophys. Acta (Molecular & Cell Biology of Lipids), 1168, 87-93 (1993)
4. Sumimoto, H., Isobe, R., Mizukami, Y. and Minakami, S., Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes, FEBS Lett., 315, 205-210 (1993)
5. 水上洋一、横山照由、合成培地によるポビドンヨードの抗菌力に関する研究、感染症学雑誌、 67, 1052-1056 (1993) (corresponding author)
6. Mizukami, Y. and Yokoyama, T., A study on the bactericidal activity of povodone-iodine : Morphological changes in Escheritia coli caused by povidone-iodine, Med. Electron Microsc., 26, 111-115 (1993) (corresponding author)
7. Mizukami, Y., Sumimoto, H., Isobe, R., Minakami, S. and Takeshige, K., ω-Oxidation of lipoxin B4 by rat liver: Identification of ω-carboxy metabolite of lipoxin B4, Eur. J. Biochem. 224, 959-965 (1994)
8. Yoshida, K., Hirata, T., Akita, Y., Mizukami, Y., Yamaguchi, K., Sorimachi, Y., Ishihara, T., and Kawashima, S., Translocation of protein kinase C-α, δ, and ε isoforms in ischemic rat heart, Biochim. Biophys. Acta, 1317, 36-44 (1996).
9. Mizukami, Y., Hirata, T., and Yoshida, K., Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase, FEBS Lett., 401, 247-251 (1997) (corresponding author)
10. Mizukami, Y. and Yoshida, K., Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion, Biochem. J., 323, 785-790 (1997) (corresponding author)
11. Yoshida, K., Kawamura, S., Mizukami, Y., and Kitakaze, M. Implication of PKC isoforms in ischemic precondioning., J. Biochem.(Tokyo), 122, 506-511 (1997)
12. Mizukami, Y., Yoshioka, K., Morimoto, S., and Yoshida, K., A novel mechanism of JNK1 activation: Nucler translocation and activation of JNK1 during reperfusion, J. Biol. Chem., 272, 16652-16662 (1997) (corresponding author)
13. Kawata, Y., Mizukami, Y., Fujii, Z., Sakumura, H.,Yoshida, K., and Matsuzaki, M., Applied pressure induces cell proliferation through mitogen-activated protein kinase activation in rat mesangial cell, J. Biol. Chem., 273, 16905-16912 (1998) (corresponding author)
14. Kikuta, Y., Kusunose, E., Sumimoto, H., Mizukami, Y., Takeshige, K., Sakaki, T., Yabusaki, Y., Kusunose, M., Purification and characterization of recombinant human neutrophil leukotriene B4 ω-hydroxylase. Arch. Biochem. Biophys., 355, 201-205 (1998) Jul 15
15. Kawamura, S., Yoshida, K., Miura, T., Mizukami, Y., and Matsuzaki, M., Ischemic preconditioning translocates PKC-δ and ε that mediates functional protection in isolated rat heart, Am. J. Physiol.(Heart and Circulatory Physiology), 275, H2266-H2271 (1998) Dec
16. Yoshida, K., Mizukami, Y., and Kitakaze, H., Nitric oxide activates protein kinase C isoforms in ischemic heart., Biochim. Biophys. Acta. 1453, 230-238 (1999) Feb 24
17. Mogami, K., Mizukami, Y., Todoroki-Ikeda, N., Ohmura, M., Yoshida, K., Miwa, S., Matsuzaki, M., Matsuda, M., and Kobayashi, S., Sphigosylphosphorylcholine induces cytosolic Ca2+ elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery., FEBS Lett., 457, 375-380 (1999) Sep3
18. Mizukami, Y., Kobayashi, S., berall, F., Karina, H., Kobayashi, N., and Yoshida, K., Nuclear mitogen-activated protein kinase activation by protein kinase C ζ during reoxygenation after ischemic hypoxia and reoxygenation, J. Biol. Chem., 275, 19921-19927 (2000)(corresponding author) Jun.30
19. Todoroki-Ikeda, N., Mizukami, Y., Mogami, K., Kusuda, T., Yamamoto, K., Miyake, T., Sato, M., Suzuki, S., Yamagata, H., Hokazono, Y., Kobayashi, S., Sphingosylphosphorylcholine induces Ca2+-sensitization of vascular smooth mucle contraction: Possible involvement of Rho-kinase, FEBS Lett., 482, 85-90 (2000)Sep. 29
20. Fujimoto, K., Mizukami, Y., Kimura, M., Todoroki-Ikeda, N., Mogami, K., Kobayashi, S., and Matsuzaki, M., Molecular cloning of rat transmembrane domain 40-kDa regulated in adipocytes and its expression in H9c2 cells exposed to ischemic hypoxia and reoxygenation, Biochim. Biophys. Acta.(Gene Structure & Expression), 1518, 173-177. (2001)(corresponding author) (Mar 19)
21. Omura, M., Kobayashi, S., Mizukami, Y., Mogami, K., Todoroki-Ikeda, N., Miyake, T., and Matsuzaki, M., Eicosapentaenoic acid (EPA) induces Ca2+-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent relaxation, FEBS Lett., 487, 361-366 (2001).Jan. 5
22. Kimura, M., Mizukami, Y., Miura, T., Fujimoto, K., Kobayashi, S., and Matsuzaki, M., G-protein-coupled receptor, GPR41, induces apoptosis via a p53/Bax pathway during ischemic hypoxia and reoxygenation, J. Biol. Chem., 276, 26453-26460 (2001). (corresponding author) Jul 13
23. Mizukami, Y., Okamura, Y., Miura, T., Kimura, M., Mogami, K., Todoroki-Ikeda, N., Kobayashi, S, and Matsuzaki, M., Phosphorylation of proteins and apoptosis induced by c-Jun N-terminal kinase activation in H2O2 stimulation, Biochim. Biophys. Acta. (Molecular Cell Research), 1540, 213-220. (2001) (corresponding author) Sep 26;
24. Aki, T., Mizukami, Y., Oka, Y., Yamaguchi, K., Uemura, K., Fujimiya, T., and Yoshida, K., Phosphatidylinositol 3-kinase accelerates necrotic cell death during hypoxia, Biochem. J., 358, 481-487(2001) Sept.1
25. Mizukami, Y., Yamada, S., Takashima, M., Kokudo, N., Yokoyama, T., Dietry iron reduces anti-convulsion activity of phenytoin in electrconvulsion via inhibition of brain penetration, Brain Res., 915, 112-117 (2001) (corresponding author) Oct 5
26. Shirao, S., Kashiwagi, S., Sato, S., Miwa, S., Nakao, F., Kurokawa, T., Todoroki-Ikeda, N., Mogami, K., Mizukami, Y., Kuriyama, S., Haze, K., Suzuki, M., Kobayashi, S., Sphingophosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+-sensitization in the bovine cerebral artery: unimportant role for protein kinase C, Circ. Res.,91(2):112-119 (2002) Jul 26
27. Nakao,F., Kobayashi, S., Mogami, K., Mizukami, Y., Shirao, S., Miwa, S., Todoroki-Ikeda, N., Ito, M., Matsuzaki, M., Involvement of Src Family Protein Tyrosine Kinases in Ca2+-Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway., Circ. Res., 91, 953-60 (2002) Nov 15
28. Eguchi, M., Fujiwara, M., Mizukami, Y., and Miwa, N., Cytoprotection by pro-vitamin C against ischemic injuries in perfused rat heart together with differential activation of MAP kinase family, J. Cell. Biochem., 89, 863-867 (2003), Aug.1
29. Aki, T., Yamaguchi K., Yoshida, K., Fujimiya, M., Mizukami, Y., Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene, 22, 8529-8535 (2003)
30. Aki, T., Yoshida, K., and Mizukami, Y., The mechanism of αB-Crystallin gene expression by proteasome inhibition, Biochem. Biophys. Res. Commun. 311, 162-167 (2003)
31. Mizukami, Y., Sumimoto, H., and Takeshige, K., Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells, Biochem. Biophys. Res. Commun. 314, 104-109 (2004), (corresponding author)
32. Yoneda, K., Iwamura, R., Kishi, H., Mizukami, Y., Mogami, K., Kobayashi, S., Identification of active metabolite of ticlopidine from rat in vitro metabolites, Brit. J. Pharmacol., 142(3):551-557 (2004) May 17
33. Mizukami, Y., Iwamatsu, A., Aki, T., Kimura, M, Nakamura, K., Nao, T., Ohkusa, T., Matsuzaki, T., Yoshida, K., Kobayashi, S., ERK1/2 regulates intracellular ATP levels through α-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation, J. Biol. Chem., 279, 50120-50131 (2004) Nov., 26. (corresponding author)
34. Hara, K., Okamoto, M., Aki, T., Yagita, H., Tanaka, H., Mizukami, Y., Nakamura, H., Tomoda, A., Hamasaki, N., Kang, D., Synergistic enhancement of TRIL- and tumor necrosis factor a-induced cell death by a phenoxazine derivative, Mol. Cancer Ther. 4 (7), 1121-1127 (2005) July
35. Funakoshi, T., Yanai, A., Shinoda, K., Kawano, M.M. Mizukami, Y., G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane, Biochem. Biophys. Res. Communi. 346, 904-910 (2006) (corresponding author)
36. Hirata,T., Cui, J. Y., Funakoshi, T., Mizukami, Y., Ishikawa, Y., Shibasaki, F., Matsumoto, M., Sakabe, T., Temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen, Brain Res., 1130 (1) 214-222 (2007) Jan 26
37. Nishina, S., Hino, K., Korenaga, M., Pietrangelo, A., Mizukami, Y., Furutani, T., Sakai, A., Okuda, M., Hidaka, I., Okita, K., Sakaida, I., Hepatitis C virus-induced reactive oxygen species causes hepatic iron accumulation by reducing hepcidin transcription, Gastroenterology, 134(1), 226-238 (2008) Jan; Epub 2007 Oct 9.
38. Tonooka, Y., Mizukami, Y., and Fujishima, M., One-base excess adaptor ligation method for walking uncloned genomic DNA, Appl. Microbio. Biotechnol, Feb;78(1):173-180. (2008) Epub 2007 Dec 11
39. Aki, T., Funakoshi, T., Nishida-Kitayama, J., and Mizukami, Y. TPRA40/GPR175 regulates mouse early embryogenesis through functional membrane transport by Sjo¨gren's syndrome-associated protein NA14, J. Cell Physiol., 217, 194-206 (2008) May 5 (corresponding author)
40. Mizukami, Y., Ono, K, Aki, T., Hatano, N., Okamoto, Y., Ikeda, Y., Ito, H., Hamano, K., and Morimoto, S., Identification and physiological activity of survival factor released during ischemia and reperfusion, Cardiovasc. Res., 79(4):589-599 (2008). Epub 2008 Jun 5. (corresponding author)
41. Matayoshi, H., Hirata, T., Yamashita S., Ishida, K., Mizukami, Y., Gondo, T., Matsumoto, M., Sakabe, T., Neurtrophil elastase inhibitor, ONO-5046, attenuates hippocampal neuronal damage after transient forebrain ischemia in rats, Brain Res. 1259, 98-106 (2009)
42. Yamashita, S., Hirata, T., Mizukami, Y. Cui, Y.J., Fukuda, S., Ishida, K., Matsumoto, M., Sakabe, T., Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase, Brain Res., 1301, 171-179 (2009)
43. Katagiri, T., Hatano, N., Aihara, M., Kawano, H., Okamoto, M., Xing, L., Izumi, T., Maekawa, T., Nakamura, S., Ishihara, T., Shirai, M., Mizukami, Y., Proteomic Analysis of Proteins Expressing in Regions of Rat Brain by Combination of SDS-PAGE with Nano-Liquid Chromatography-Quadrupole Tandem Mass spectrometry, Proteome Science, 8, 41-53 (2010). [Epub ahead of print] (2010) Jul 27 (corresponding author)
44. Takemoto Y, Li TS, Kubo M, Ohshima M, Ueda K, Harada E, Enoki T, Okamoto M, Mizukami, Y., Murata T, Hamano K., Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells, Surgery, 149, 792-800. Epub (2011) Apr 20.
45. Yoshida M, Ohkusa T, Nakashima T, Takanari H, Yano M, Takemura G, Honjo H, Kodama I, Mizukami, Y., Matsuzaki.M., Alterations in adhesion junction precede gap junction remodeling during the development of heart failure in cardiomyopathic hamster., Cardiovasc. Res., 92, 95-105 (2011), Epub 2011 Jun 21. (2011)
46. Aihara, M., Yamamoto, S., Nishioka, H., Inoue Y., Hamano, K., Oka, M., and Mizukami, Y., Optimizing high-resolution melting analysis for the detection of mutations of GPR30/GPER-1 in breast cancer, Gene 501, 118-126, (2012) (corresponding author)
47. Nakashima, T., Ohkusa T., Yoshida M., Lee J.-K., Mizukami, Y., Yano M., Alterations in cardiac β-catenin precede connexin gap junction remodeling in cardiomyocytes exposed to rapid electrical stimulation, Am. J. Physiol. (Heart and Circulatory Physiology), 306, H1324-1333 (2014), Epub 2014 Mar 7.
48. Akiyoshi Y., Izumi T., Oda Y., Mizukami, Y., Tsuruta R., Maekawa T., Analysis of cerebrospinal fluid proteins reveals association of calbindin 1 concentrations with neurological outcome in patients resuscitated from cardiopulmonary arrest: A proteomics based pilot study, Bulletin of Yamaguchi Med., 61, 23-35 (2014)
49. Utada, K., Ishida, K., Tohyama, S., Urushima, Y., Mizukami, Y., Yamashita, A., Uchida, M., Matsumoto, M., The combination of insulin-like growth factor 1and erythropoietin protects against ischemic spinal cord injury in rabbits, J. Anesthesia, 29, 741-748 (2015). Epub 2015 May 24
50. Mimura, Y.,Kelly, R.M.,Unwin, L., Albrecht, S., Jefferis, R., Goodall, M., Yoichi Mizukami, Y., Mimura-Kimura, Y., Matsumoto, T., Ueoka, H., Pauline M Rudd, P.M., Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines, J. Immunol Methods, in press

著書・総説

1. Yoshida, K., Mizukami, Y., and Harada, K., Translocation and activation of protein kinase C-α, δ, and ε isoforms in rat heart, Choei Wakasugi (ed.), Advances in Legal Medicine 3, 131-134, Yoyodo, (1997)
2. 吉田謙一、水上洋一、原田一樹、一酸化窒素は虚血再灌流時のラット心筋protein kinase C isoformを活性化する、心筋の代謝と構造、20, 309-312, 六法出版社 (1998)
3. 水上洋一, 住本英樹、P-450によるアラキドン酸代謝、現代医療, 31, 131-140 (1999)
4. 水上洋一, 心筋梗塞後のアポトーシスを制御する核内MAPK活性化経路―生理活性脂質によるPKCζの核移行の関与―, 医科学応用研究財団研究報告, 18, 157-161, (1999)
5. 轟-池田奈津子、白尾敏之、佐藤正史、山本哲、最上紀美子、水上洋一、小林誠、スキンド法による血管の細胞内シグナル伝達の評価法、山口医学, 49, 449-451 (2000)
6. 水上洋一　心筋虚血によって分泌する低分子化合物―細胞死のシグナルを制御する物質―, 上原記念生命科学財団研究報告集, 14, 175-177 (2000)
7. 水上洋一　心機能を制御する新規生理活性脂質の解明、小野医学研究財団年報11, 27 (2000)
8. 水上洋一、心筋虚血における細胞内シグナル伝達、山口医学, 50, 563-568 (2001)
9. 白尾敏之、柏木史郎、轟ー池田奈津子、最上紀美子、水上洋一、鈴木倫保、小林誠、脳血管平滑筋におけるCa2+非依存性収縮の分子機構：スフィンゴ脂質とCキナーゼ、脳血管攣縮, 16, 279-282 (2001)
10. 柏木史郎、白尾敏之、轟ー池田奈津子、最上紀美子、水上洋一、鈴木倫保、小林誠、脳血管におけるSphigosylphosphorylcholineによるRho-kinaseの活性化を介したCa2+非依存性異常収縮について、脳血管攣縮, 16, 287-289 (2001)
11. 水上洋一、岩松明彦、小林誠、ストレスに応答してMAPK活性化によって誘導される心筋機能保護因子ー心筋梗塞モデルでの検討ー、臨床薬理の進歩、22、130-133 (2001)
12. 水上洋一、オーファン受容体は宝のヤマ？、山口医学, 50, 763-769 (2001)
13. 木村征靖、三浦俊郎、藤本紀代子、松崎益徳、水上洋一、小林誠、G protein-coupled orphan receptorであるGPR41は虚血再灌流刺激にてp53とBaxを介したアポトーシスを誘導する、アポトーシス、心不全の発症と心筋アポトーシスおよび動脈硬化とアポトーシスの研究、5、17-21 (2001)
14. 水上洋一, 心筋虚血に応答するオーファン受容体のリガンド探索, 東京生化学研究会助成研究報告集, 16, 94-99 (2001)
15. 水上洋一, ゲノム創薬, 中国四国地区国立大学間共同授業手引き, 5-6 (2002)
16. Mizukami, Y., Mitogen-activated protein kinase pathway in ischemic heart, Recent Reseach Development in Biological Chemistry, Reseach Signpost 1, 13-27 (2002) review
17. 水上洋一、心筋虚血時に誘導される新規細胞死受容体の機能解明、財団法人　山口老年医学研究所　年報16, 1-5, 2002
18. 水上洋一, 心筋低酸素ストレスに応答するオーファン受容体の機能解明, 持田記念財団年報, 14, 153-156 (2002)
19. 水上洋一, 疾患誘発因子の工業的同定法の確立と医薬品への応用, 新技術フォーラムin やまぐち, 63-66 (2002)
20. Aki, T. and Mizukami, Y. The role of phosphoinositide 3-kinase in ischemiac heart, Recent Research Development in Biochmistry, Reseach Signpost, 4, 671-683, review(2003)
21. 水上洋一, ストレスが癌をつくる！？,癌と人, 30, 36-37 (2003) 財団法人　大阪癌研究会発行
22. Aki, T., and Mizukami, Y., Regulation of Cardiomyocyte functions by distinct phosphoinositide 3-kinase, “Molecular Mechanisms of Heart diseases”, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, 85-99 (2005)
23. Kimura, Y, and Mizukami, Y.,and Matsuzaki, M., Orphan G protein-coupled receptor and ischemia, “Molecular Mechanisms of Heart diseases”, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, 99-113 (2005)
24. 水上洋一　性ステロイドホルモンとGPCR, 実験医学, 8, 2080-2086, (2009)
25. Mizukami, Y., In vivo functions of GPR30/GPER-1, a membrane receptor for estrogen-From discovery to functions in vivo-, Endocrine J., 57(2), 101-107 (2010). Epub 2009 Dec 8.
26. 水上洋一, 細胞膜エストロゲン受容体GPER/GPR30は,なぜ小胞体で見つかったのか！日本薬理学会誌, 138, 130 (2011)
27. 水上洋一, 渡邊健司, 坂口修一, ―次世代シーケンサーの現状と問題点について-,第5章10節　遺伝子・DNA利用も製品開発におけるガイドラインでは分からない規制・倫理対応と解析、操作技術のトラブル対策、(株)技術情報協会 編(2014) May 30
28. 狩生徹，井上雄太郎，水上洋一, 半導体マイクロチップ対応次世代シーケンサーを用いたがん関連遺伝子の解析, 山口医学63　(4) 253-256 (2014)